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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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Search results for , issue "JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014" : 7 Documents clear

Jurnal IlmuFarmasi& FarmasiKlinik Volume 11 No. 2 Desember 2014 Fakultas Farmasi
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014
Publisher : Universitas Wahid Hasyim Semarang

iJurnalIlmuFarmasi&FarmasiKlinikJournal of Pharmaceutical Science & Clinical PharmacyPemimpin Umum/Penanggung jawabDekan Fakultas Farmasi Universitas Wahid HasyimPemimpin RedaksiKetua Program StudiFarmasiFakultas Farmasi Universitas Wahid HasyimRedaktur AhliDr. Sumantri, M.S., AptProf. Dr. Suwijiyo Pramono, AptProf. Dr. Mustofa, MKes, AptDr. Mimiek Murukmihadi, SU., AptRedakturPelaksanaDevi Nisa Hidayati, S.Farm, M.Sc.Staf Redaksi :Ellya Zulfa, S.Farm., M.Sc., Apt.Dewi Andini Kunti, S.Farm., M.Sc.Kiki Damayanti, S.FarmSekretaris RedaksiRirin Lispita Wulandari., S.Farm.,M.Si.Med., Apt.DistributorRachmad WahyudiAlamat Redaksi/Tata UsahaFakultas Farmasi Universitas Wahid HasyimJl. Menoreh Tengah X/22 Sampangan SemarangTelp. 024-8505680, 8505681 Fax. 024-8505680E-mail : jurnalfarmasiuwh@yahoo.co.idTerbit 2 kali setahun sejak September 2004ISSN : 1693-7899Volume 11 No. 2 Desember 2014 2014iiJurnalIlmuFarmasi&FarmasiKlinikJournal of Pharmaceutical Science & Clinical PharmacyDAFTAR ISIKajian Reversibilitas Interaksi Marmin terhadap Reseptor Histamin H1, Asetilkolin Muskarinik Ach-M3 dan B2 AdrenergikYance Anas, Agung Endro Nugroho, Sugeng Riyanto.………………………………1-8Uji Aktivitas Antioksidan Ekstrak Etanolik Kulit Buah Jeruk Nipis (Citrus aurantifolia) Dengan Metode DPPH (1,1-difenil-2-pikrilhidrazil)Ismiyyatun Khasanah, Maria Ulfah, Sumantri……………………………….............Perbedaan Hasil Evaluasi Pengelolaan Obat Puskesmas ISO dan Non ISO Kota Semarang Tahun 2013Risha Fillah Fithria, Ika Desti Pratiwi………………………………………..............9-1718-26Pengaruh Kombinasi Ekstrak Terpurifikasi Herba Artemisia (Artemisia annua (L.))dan Herba Sambiloto (Andrographispaniculata (Burm.f) Nees) Terhadap Kadar Glukosa Darah pada Tikus Diabetes Mellitus Tipe 2 Resisten InsulinKyky Herlyanti, Yuvianti Dwi Franyoto, Etty Sulistyowati……………....................27-31Efek Pemberian Glukomanan Umbi Porang(Amorphophallusoncophyllus Prain ex Hook. f.)Terhadap Kadar Kolesterol Total Darah Tikus yang Diberi Diet Tinggi LemakBekti Nugraheni, Intan Martha Cahyani, Kyky Herlyanti……………………………32-36Disolusi Asam Mefenamat Dalam Sistem Dispersi Padat Dengan PEG 4000Yulias Ninik Windriyati, Sugiyono, Lies Sunarliawati……………………………....37-41ISSN : 1693-7899Volume 11 No. 2 Desember 2014

KAJIAN REVERSIBILITAS INTERAKSI MARMIN TERHADAP RESEPTOR HISTAMIN H1, ASETILKOLIN MUSKARINIK Ach-M3 dan β2-ADRENERGIK Yance Anas; Agung Hendro Nugroho; Sugeng Riyanto
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Penelitian terdahulu menyimpulkan bahwa marmin (7-(6’,7’-dihidroksigeranil-oksi) kumarin) dapat menghambat kontraksi otot polos trakea marmut terisolasi melalui efeknya sebagai antagonis reseptor H1 dan Ach-M3. Marmin juga sedikit meningkatkan efek relaksasi otot polos trakea yang diinduksi oleh isoproterenol melalui interaksinya terhadap reseptor β2-adrenergik. Penelitian ini bertujuan untuk mengevaluasi efek reversibelitas interaksi marmin terhadap reseptor H1, Ach-M3 dan β2-adrenergik. Penelitian ini menggunakan metode percobaan organ terisolasi. Uji reversibilitas dilakukan setelah perlakuan marmin (10 dan 100 μM) terhadap kontraksi/relaksasi otot polos trakea yang diinduksi oleh agonis (histamin, metakolin dan isoproterenol). Otot polos trakea dicuci selama 30 menit dengan penggantian larutan bufer Krebs setiap lima menit. Setelah dicapai kondisi yang stabil, selanjutnya dilakukan pengukuran kontraksi atau relaksasi kembali dengan pemberian konsentrasi bertingkat histamin (10-8 – 10-3) M, metakolin (10-8 – 10-3) M dan isoproterenol (1 x 10-7 – 3 x 10-3 M). Data disajikan dalam bentuk nilai pD2 (rata-rata ± SEM) yang diperoleh dari kurva hubungan negatif logaritma konsentrasi agonis yang menghasilkan setengah respon (kontraksi/relaksasi) maksimal. Hasil penelitian menunjukkan bahwa interaksi marmin terhadap protein reseptor H1, Ach-M3, dan β2-adrenergik otot polos trakea bersifat reversibel. Hasil analisis varian satu jalan menyimpulkan perbedaan nilai pD2 histamin, metakolin dan isoproterenol sebelum dan setelah perlakuan marmin tidak bermakna secara statistik (p>0,05). Kata Kunci : Farmakodinamik marmin, uji reversibelitas, reseptor H1, Ach-M3 dan β2–adrenergik, percobaan organ terisolasi ABSTRACT Previous studies concluded that amarmin(7 - (6 ', 7'-dihidroxygeranyl-oxy) coumarin) shown to inhibit isolated guinea-pig tracheal smooth muscle contraction through its effect as an H1and Ach-M3receptor's antagonist. Marmin also slightly increases tracheal smooth muscle relaxation induced by isoproterenol through its interaction on β2-adrenergic receptor. The purpose of this experimental study was to evaluate the reversibility of marmin interaction on H1, Ach-M3 and β2-adrenergic receptors.The study conducted using in vitro isolated-trachea experimental. Reversibility studies performed after marmin (10 and 100) μM treatment on tracheal smooth muscle contraction/relaxation induced by agonists (histamine, methacholine and isoproterenol). Trachea was washed for 30minuteswith Krebs buffer solution replacement every five minutes. Furthermore, trachea contracted or relaxed with series histamine (10-8 – 10-3) M; methacholine (10-8 – 10-3) M and isoproterenol (10-7 – 3.10-3) M. Data were expressed as mean±SEM. The pD2values are derived from the negative logarithm to base 10 of the agonist's concentration which cause a half maximal response to the contraction or relaxation.The results showed that the marmin interaction on H1, Ach-M3, and β2-adrenergic receptors are reversible. One-way Anova concluded that histamine, metacholine and isoproterenol pD2 value before and after marmin (10 and 100) μM treatments are not different statistically (p>0.05). Key Word : Marmin reversibility studies, H1, Ach-M3 and β2-adrenergic receptors, isolated organ experimen

UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOLIK KULIT BUAH JERUK NIPIS (Citrus aurantifolia) DENGAN METODE DPPH (1,1-difenil-2- pikrilhidrazil) Ismiyyatun Khasanah; Maria Ulfah; Sumantri Sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTCitrus aurantifolia is known contains flavonoid compound and high Vitamin C. One of theeffects of flavonoid and Vitamin C are antioxidant. This research aims to knowing the antioxidantactivity of citrus aurantifolia etanolic extract by using the DPPH (1, 1-difenil-2-pikrilhidrazil) methodand to knowing the active compound that containing whithin.The research was done by making level series of citrus aurantifolia etanolic extract, they were10, 20, 40 and 80 μg/ml. As a standard of comparison was used vitamin C with concentrations 1, 2, 4and 8 μg/ml. As a blank was used DPPH 0,1 mM. The antioxidant activity test was done by the DPPHmethod. The achieved data was counted to know it’s antioxidant activity. The statistical analysis wasused T-Test. To know IC50 (Inhibition Concentration)50 was used the probit analysis and to know it’sactive compound content was done an identification with TLC (Thin Layer Chromatography).The result of the research shows that etanolic extract of citrus aurantifolia has antioxidantactivity IC50 about 54,458 μg/ml and 4,768 μg/ml for vitamin C. The statistical test result of antioxidantactivity shows that there is no any significant difference. The TLC result shows that compoundcontained in etanolic extract of citrus aurantifolia are flavonoid and Vitamin C.Keywords: Citrus aurantifolia extract, DPPH method, antioxidant and IC50.

PERBEDAAN HASIL EVALUASI PENGELOLAAN OBAT PUSKESMAS ISO DAN NON ISO KOTA SEMARANG TAHUN 2013 Risha Fillah Fithria; Ika Desti Pratiwi
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTEmptiness and breakage of drugs in health centers often leads to non ISO patient dissatisfaction, which might be due to non optimal medication management. This study was conducted to determine the differences of the evaluation result of drug management between ISO and non ISO health centers in Semarang at 2013.This type of research is analytic survey, with a sample of three of most visits ISO and non-ISO health centers and non-ISO. Retrospective data collection techniques along with free interview directed to drug manager. Materials and research tools were card stock, report morbidity data (LB1), recipes, and the inventory check. Data were evaluated every month used the indicators of the Ministry of Health of Indonesia in 2010 and were analyzed used independent sample t test and Mann Whitney.The result showed that there was difference of the evaluation result of drug management between ISO and non ISO health centers in Semarang at 2013 on indicator of available drugs item complies with DOEN (t <1.66691) and the percentage of generic drugs writing (t <1.66691).Keywords : Drug Management, ISO Health Centers, Non ISO Health Centers, Semarang City

PENGARUH KOMBINASI EKSTRAK TERPURIFIKASI HERBA ARTEMISIA (Artemisia annua (L.)) DAN HERBA SAMBILOTO (Andrographis paniculata (Burm.f) Nees) TERHADAP KADAR GLUKOSA DARAH PADA TIKUS DIABETES MELLITUS TIPE 2 RESISTEN INSULIN Kiki Herliyanti; Yuvianti Dwi Franyoto; Etty Sulistyowati
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTInsulin resistance is a common condition that is believed to play a major role in the pathogenesis of the metabolic syndrome, obesity and type 2 diabetes mellitus, and heart disease. The purpose of this study was to determine the antidiabetic activity mellitus combination of purified extract of bitter herbs and artemisia herb in rats with type 2 diabetes mellitus insulin resistance compared with the effect of each extract.Test activity of purified extract of bitter herbs, herbal extracts purified artemisia and combinations thereof done by grouping test animals which have been declared insulin resistance is divided into 7 groups, Group I: a combination of purified extract of bitter herbs 390.9 mg / kg and 83.56 mg of the herb artemisia / kg; Group II: a combination of purified extract of bitter herbs 651.5 mg / kg and herb artemisia 41.7 mg / kg; Group III: purified extract of bitter herbs single dose of 651.5 mg / kg rat; Group IV : purified extract of bitter herbs single dose of 1303 mg / kg, po; Group V: purified extract of the herb artemisia single dose 41.78 mg / kg, po; Group VI: purified extract of the herb artemisia single dose 83.56 mg / KgBW , po; Group VII: positive control (given metformin dose of 45 mg / kg, po); Group VIII: negative control (CMC-Na was given 1%, po). Then the results were analyzed with SPSS 16 statistical test.The percentage decrease preprandial blood glucose levels of administration of a single dose of artemisia extract 83.56 mg / KgBW better than the combination of bitter and herbal28extracts artemisia, while the percentage reduction in postprandial glucose levels in the administration of a combination of extracts of bitter herbs bitter dose of 651.5 mg / kg BB artemisia herb and 41.7 mg / kg better than the extract of bitter herbs and herbal extracts artemisia singly.Keywords: bitter herbs, Artemisia herb, diabetes mellitus, glucose levels

EFEK PEMBERIAN GLUKOMANAN UMBI PORANG (Amorphophallus oncophyllus Prain ex Hook. f.) TERHADAP KADAR KOLESTEROL TOTAL DARAH TIKUS YANG DIBERI DIET TINGGI LEMAK Bekti Nugraheni; Intan Martha Cahyani; Kyky Herlyanti
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTIndonesia is a country with abundant natural resources, one of which tubers. Plants types of tubers that have a lot of glucomannan content of the tuber porang. Glucomannan is used as a diet in patients with hypercholesterolemia. Glucomannan from tubers porang (Amorphophallus oncophyllus Prain ex Hook.f.) serves as a water-soluble fiber and have a low calorie.The purpose of this study was to determine the effect of glucomannan tuber porang (Amorphophallus oncophyllus Prain ex Hook.f.) to decrease total blood cholesterol mice fed a high-fat diet and to determine what dose of glucomannan tubers porang most effective for lowering blood cholesterol.The treatment in this study is glucomannan flour dose of 25 mg / kg; 50 mg / kg; and 100 mg / kg. The population in this study was a white rat (Rattus norvegicus) males aged 2-3 months with BB ± 200 g.Giving glucomannan porang tubers dose 25 mg / kg; 50 mg / kg; and 100 mg / kg give effect to the reduction in total blood cholesterol mice fed a high-fat diet. Effective dose for lowering total cholesterol levels of mice that is 50 mg / kg.Keywords: glucomannan tuber porang (Amorphophallus oncophyllus Prain ex Hook.f.), total cholesterol.

DISOLUSI ASAM MEFENAMAT DALAM SISTEM DISPERSI PADAT DENGAN PEG 4000 Yulias Ninik Windriyati; Sugiyono Sugiyono; Lies Sunarliawati
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTMefenamic acid is an analgetic that insoluble in water and classified into class II in theBiopharmaceutic Classification System (BCS), therefore the dissolution become the rate limitingstep of absorption process and bioavailability. Several approaches are required to improve thedissolution like preparation of solid dispersion. The aim of this research is to know the dissolutionof mefenamic acid in solid dispersion system with PEG 4000.Solid dispersion of mefenamic acid-PEG 4000 were prepared by fusion method withcontain PEG 4000 for FI (20%), FII (40%), FIII(60%), FIV (80%) and FV (100%) respectivelywere compared with the weight of mefenamic acid. The powder of solid dispersion systems wereinvestigated for its recovery and dissolution in medium fosfat buffer pH 7.4 until 60 minutes. Puremefenamic acid and the physical mixture with polimer were used as compared powders. Theresult of dissolution testing were revealed by Dissolution Efficiency (DE60)The result showed that PEG 4000 can increased the dissolution of mefenamic acid fromsolid dispersion systems. The DE60 of mefenamic acid-PEG 4000 from FI 30,41%; FII 30,60%;FIII 36,19%; FIV 36,42%; FV 41,92%; and the physical mixture of FV 23,63% respectively. Thevariations of concentration of PEG 4000 in this solid dispersion not influence the dissolution ofmefenamic acidKeywords : Mefenamic acid, PEG 6000, PVP, solid dispersion, dissolution

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